Editorial Perspectives: will SARS-CoV-2 reset public health requirements in the water industry? Integrating lessons of the past and emerging research
The workers, who were part of a crew building a football stadium, were taken in the mainly Shi'ite Habibiya district in northeastern Baghdad.
Editorial Perspectives: 2019 novel coronavirus (SARS-CoV-2): what is its fate in urban water cycle and how can the water research community respond?
Targeted poverty alleviation
Nano and biosensors for detection of SARS-CoV-2: challenges and opportunities
Soft matter science and the COVID-19 pandemic
Such highlighted talents also include cult director David Lynch of the United States and the versatile Taiwan filmmaker Sylvia Chang, whose representative works are on the recommended lineup.
Carbon-based antiviral nanomaterials: graphene, C-dots, and fullerenes. A perspective
Turkey’s president ratcheted up his diplomatic row with the Netherlands on Tuesday, claiming the country had a “rotten character” and blaming Dutch troops for the worst massacre in Europe since the second world war.
Ultraviolet-C and other methods of decontamination of filtering facepiece N-95 respirators during the COVID-19 pandemic
'It surprised me, but it's a good sign for Tencent getting abroad, because in particular WeChat is a combination of WhatsApp and Instagram, so it's a unique value proposition that is probably pretty good for emerging market consumers,' he said.
New investment in Europe was up 28 per cent on the $18bn registered in 2014, a smaller increase than 2014’s doubling of the 2013 figure. Investment in the US was up 17 per cent compared on 2014’s level of $12.8bn.
Trends and targets in antiviral phototherapy
While the WeChat use of the "post-90s" generation has slightly decreased, from 94.1 percent to 86.6 percent.
President Xi Jinping is also a well-known football fan, who has repeatedly voiced his support for the sport's development in China.
A new point-of-care test for the diagnosis of infectious diseases based on multiplex lateral flow immunoassays
Novel biosensing methodologies for ultrasensitive detection of viruses
‘Veep’ “House of Cards,” the Netflix phenomenon, showed its weaknesses this year, but HBO’s “Veep,” the other most cynical show about Washington, got stronger in its third season. The scene in a restroom in which Selina (Julia Louis-Dreyfus) and her assistant, Gary (Tony Hale) discover that she is going to become president and dissolve into uncontrollable laughter was one of the great comic moments of 2014.
Anti-tumor, -viral, and -bacterial activities of polyoxometalates for realizing an inorganic drug
ACE2 as a potential therapeutic target for pandemic COVID-19
On China's Twitter-like Weibo, many netizens thumbed up the boy's bravery and calmness in the face of such emergency.
Diagnostic technologies for COVID-19: a review
Targeting severe acute respiratory syndrome-coronavirus (SARS-CoV-1) with structurally diverse inhibitors: a comprehensive review
"The editors thought the articles were being sent out to genuine reviewers in the discipline," he said. "Following our investigation and communication with the real reviewers, they confirmed they did not conduct the peer review."
Probably the most awaited movie of all time and a big one for all Batman and Superman fans. We know that Batman is going to defeat Superman, but we don't know how he's going to do so in Dawn of Justice.
An overview of key potential therapeutic strategies for combat in the COVID-19 battle
Potential repurposed SARS-CoV-2 (COVID-19) infection drugs
The Lord of the Rings trilogy. The amount of time before I need an oil change. My cell phone's battery charge. What do all of these things have in common? The
2. The 2012 Ig Nobel Peace Prize
Nature as a treasure trove of potential anti-SARS-CoV drug leads: a structural/mechanistic rationale
"Apple, Google and Coca-Cola are the most valuable brands as their finances are strong, their brand is a powerful driver of choice and they are very strong compared to competitors," said Jez Frampton, Interbrand's global chief executive officer.
In search for effective and definitive treatment of herpes simplex virus type 1 (HSV-1) infections
Antiviral drug discovery: broad-spectrum drugs from nature
In 2011, some seven years after the last season of Friends, over 36 million tuned into Comedy Central, a US satellite TV channel, to watch the show. The main demographic for this channel is 16 to 34 year olds, and viewing figures spiked during holidays, when extra episodes are also shown.
《副总统》(Veep)：Netflix公司的热门剧《纸牌屋》(House of Cards)今年露出疲态，但另一部讽刺华盛顿的HBO电视剧《副总统》却在第三季中更上一层楼。塞琳娜（朱莉娅·路易斯-德莱弗斯[Julia Louis-Dreyfus]饰）和助手加里（Gary，托尼·黑尔[Tony Hale]饰）在洗手间里发现自己即将成为总统后，激动得失声大笑，成为2014年喜剧片中最滑稽的一幕。
After a run with One Direction, Harry Styles could have gone anywhere he wanted.
Influenza neuraminidase: A druggable target for natural products
That's particularly striking in Brazil, with its highly mixed population that has more blacks than any country with the exception of Nigeria. More than half of Brazil's population self-identified themselves as black or of mixed-race in the 2010 census.
Emerging investigators series: the source and fate of pandemic viruses in the urban water cycle
但1998年的记录现已被每四、五年一次的新记录多次打破，而2014年的记录是在没有显著厄尔尼诺现象发生的年度创下的。加文·A·施密特(Gavin A. Schmidt)是位于曼哈顿的美国宇航局戈达德太空研究所的所长，他说，下一次的强厄尔尼诺现象可能会打破所有的温度记录。
The role of biosensors in the detection of emerging infectious diseases
Quantitative determination of mechanical stability in the novel coronavirus spike protein
THE NIGHTLY SHOW WITH LARRY WILMORE (Comedy Central, Jan. 19) Mr. Wilmore’s topical comedy show replaces “The Colbert Report” at 11:30 p.m. and represents the latest opportunity to introduce some diversity to late-night programming. No pressure there!
Interaction of hydroxychloroquine with SARS-CoV2 functional proteins using all-atoms non-equilibrium alchemical simulations
Song “Happiness” (Mao A’Min)
If you want a refrigerator with a screen, might as well just stick an iPad on it. Samsung unveiled a smart refrigerator this summer that connects to wi-fi to help manage groceries and leave notes behind for family members.
Wang Jie, the general manager of a Beijing-based investment company, said the higher pay for executives in the financial and real estate industries shows the imbalance of development in China.
MPLEx: a method for simultaneous pathogen inactivation and extraction of samples for multi-omics profiling
It plans to help at least 130,000 rural people cast off poverty and relocate 163,000 residents in 2017.
Multicolored silver nanoparticles for multiplexed disease diagnostics: distinguishing dengue, yellow fever, and Ebola viruses
With his technical genius and startup launched, he's not planning on going back and finishing high school, either."This is my third time applying for the Fellowship. I first applied when I was 14," he said. "I told my parents when I first applied and they weren’t really supportive. But then they kind of saw what I was doing in high school, I wasn’t spending my time as effectively as I could. I started spending more of my time at MIT and they understood. When I did receive the fellowship, they were supportive."Fortunately for Sohmers, he's in good hands. He's part of class No. 3 and Thiel fellows have a promising track record so far: it's launched 67 companies that have created 135 full-time jobs and raised $55.4 million in angel and venture funding, the Wall Street Journal's Lora Kolodny reports.At 17, Sohmers is unconcerned that being a high-school dropout will affect his career in any way."If I don’t end up changing the world with this I can find something else," he said. "People think that there’s a big thought war between these two sides [education versus entrepreneurship]. But when it comes to the researchers, they care less about the degrees that you have, and more about what you can actually do."
At age 20, the teen prodigy of "Royals" raised the bar, marrying the massive vistas of electronic music alongside the human-scaled and handmade on her second LP, with help from co-producer Jack Antonoff.
Inhibition of SARS coronavirus helicase by bismuth complexes
The relocation is also part of the integration plan for the Beijing-Tianjin-Hebei cluster, which aims to ease congestion in the capital and achieve more balanced development in the region.
James Gorman, a Times reporter, accompanied scientists who are trying to understand the genes that distinguish dogs from wolves. Humans who raise wolf puppies must spend 24 hours a day, seven days a week with them in order to socialize these puppies for scientific study. And while the pups may seem cute, they will grow to be predatory wolves, not humanity’s faithful companions. The researchers hope their work will help reveal the trigger that made some ancient wolves into the dogs we know today.
Unveiling the molecular mechanism of SARS-CoV-2 main protease inhibition from 137 crystal structures using algebraic topology and deep learning
"Quality supervision authorities at all levels must intensify quality supervision and keep cracking down on law violations to improve the quality of products and protect consumers' rights," said Mei Kebao, deputy head of the administration.
With the momentum now back behind the iPhone and anticipation growing for the Watch, Mr Cook seems to have won back the confidence of Apple employees, something that analysts say was obvious in his demeanour at this year’s product launches.
A serological aptamer-assisted proximity ligation assay for COVID-19 diagnosis and seeking neutralizing aptamers
Revealing the molecular mechanisms of proteolysis of SARS-CoV-2 Mpro by QM/MM computational methods
The molecular mechanism of the proteolysis reaction catalyzed by SARS-CoV-2 Mpro, one of the enzymes essential for the replication process of the virus responsible for the COVID-19 pandemic, is described using computational QM/MM methods.
Multi-targeting of functional cysteines in multiple conserved SARS-CoV-2 domains by clinically safe Zn-ejectors
By combining evolutionary and physico-chemical principles, previously unknown druggable Zn-sites in multiple conserved SARS-CoV-2 domains have been identified.
Computer-generated “synthetic contingency” plans at times of logistics and supply problems: scenarios for hydroxychloroquine and remdesivir
香港科技大学(Hong Kong University of Science and Technology)和凯洛格管理学院(Kellogg School of Management)合办的中美EMBA项目重新夺回英国《金融时报》100个最佳EMBA项目排行榜的冠军宝座。
Engineered unnatural ubiquitin for optimal detection of deubiquitinating enzymes
She created a whole world around the device -- one populated by humans, a whale in a top hat and dragons.
A Digital Protein Microarray for COVID-19 Cytokine Storm Monitoring
Accelerating the repurposing of FDA-approved drugs against coronavirus disease-19 (COVID-19)
A point-of-care selenium nanoparticle-based test for the combined detection of anti-SARS-CoV-2 IgM and IgG in human serum and blood
Supply-side structural reform: Cutting overcapacity, destocking, deleveraging, reducing costs and identifying growth areas
Assessing potential inhibitors of SARS-CoV-2 main protease from available drugs using free energy perturbation simulations
Similar to quick LinkedIn overhauling, Foss says employers will likely notice if you abruptly go from tweeting cat GIFs and "Game of Thrones" spoilers to posting thoughtful, industry-focused content and participating in job-search Twitter chats. These are generally good moves for your job search, but bad ones for keeping it under wraps, so again, take it slow。
Online sales contributed 82.6 percent of sales. Online sales have prompted traditional stores, including 13 of Beijing's 77 "time-honored brands" from snack stores to shoes sellers, to move their goods online.
The inactivation mechanism of chemical disinfection against SARS-CoV-2: from MD and DFT perspectives
Hurun Chairman Rupert Hoogewerf said: "Those entrepreneurs should be called 'super wealth creators' instead of simply 'rich people', which could highlight their contribution to China's society and economy."
Few years in recent decades dawned with as much of a sense of pessimism as 2014. One consistent theme in the predictions for the year was that 2014 looked eerily similar to 1914. Most pundits predicted doom and gloom, especially in east Asia. Yet, while there were many horrific events — from thedowning of flight MH17 over Ukraine, to the abduction of hundreds of schoolgirls in Nigeria and the rise of the Islamic State of Iraq and the Levant — we have avoided outright world war. Now that the year is closed, with no repetition of 1914, it may be wise to investigate why the pundits were wrong, particularly on their ideas around the potential for conflict in Asia.
Antiviral agents against COVID-19: structure-based design of specific peptidomimetic inhibitors of SARS-CoV-2 main protease
A jailed con artist who falls in love with another inmate and escapes prison multiple times could only be the work of fiction, but this is more or less the real story of Steven Jay Russel. Much like his film counterpart, played by Jim Carrey, Russell was originally sent to prison for fraud. He escaped his first sentence to be with his partner Jim Kemple, who at the time was dying from AIDS. Russell was found two years later and returned to prison. Kemple died soon after.
Pharmacophore-based approaches in the rational repurposing technique for FDA approved drugs targeting SARS-CoV-2 Mpro
●"Woman arrested for defecating on boss’ desk after winning the lottery"
Amino acid interacting network in the receptor-binding domain of SARS-CoV-2 spike protein
Greener liquid-phase synthesis and the ACE inhibitory structure–activity relationship of an anti-SARS octapeptide
Taken together, these events and strategic initiatives highlight the Chinese aerospace industry’s realization that, in order to become a globally competitive player, it will need depth as much as breadth. After getting their hands on both ends of the value chain—aircraft design and final assembly—the Chinese now understand that what will make or break their industry over the long term is what happens in the middle of the value chain, at the component and subsystem levels. And that is why China’s ambition to compete with Boeing and Airbus, as well as with GE and Rolls-Royce for aircraft engines, is now more credible than ever.
Contrary to the consensus view -- which assumes that smartphones in China will only get cheaper -- she cites research showing that the average selling price stablized last yearand has actually started to increase as Chinese users trade up to higher-quality smartphones.
Anti-inflammatory, antiallergic and COVID-19 protease inhibitory activities of phytochemicals from the Jordanian hawksbeard: identification, structure–activity relationships, molecular modeling and impact on its folk medicinal uses
Promoting social development to ensure and improve the wellbeing of our people
Landing a superstar like Cousins for pennies on the dollar won't singlehandedly help the Pelicans carve out a larger slice of the sports landscape in New Orleans, but it's an excellent first step.
The biomaterial polyphosphate blocks stoichiometric binding of the SARS-CoV-2 S-protein to the cellular ACE2 receptor
CareerCast.com, a career website owned by Adicio Inc., ranked 200 jobs from best to worst based on five criteria: physical demands, work environment, income, stress, and hiring outlook. The firm used data from the Bureau of Labor Statistics and other government agencies to determine the rankings. As in prior years, the 200 jobs were selected for their relevance in the current labor market as well as the availability of reliable data.
Two of Summly’s employees will move to Yahoo’s California headquarters, but – for now – Mr D’Aloisio is resisting the lure of Silicon Valley.
And while many Bond girls fade into acting obscurity or fall into second-class flicks after making a 007 splash, Marlohe and her agents at ICM Partners are making sure the actress surrounds herself with top-flight talent as she uses the Bond movie as a launching pad for an international career.
Ilimaquinone (marine sponge metabolite) as a novel inhibitor of SARS-CoV-2 key target proteins in comparison with suggested COVID-19 drugs: designing, docking and molecular dynamics simulation study
考虑到波士顿咨询集团(Boston Consulting Group)管理合伙人理查德莱塞(Richard Lesser)的第二任期将于10月结束，该公司可能也将引来变化。然而，由于该公司拒绝就其选举流程及领导人最多可以有几个任期置评，莱塞的未来尚不明确。
Design and optimization of a subunit vaccine targeting COVID-19 molecular shreds using an immunoinformatics framework
Several coumarin derivatives and their Pd(II) complexes as potential inhibitors of the main protease of SARS-CoV-2, an in silico approach
Coumarin derivatives and their Pd(II)-complexes have shown a higher binding potential towards SARS-CoV-2 Mpro than chloroquine/cinanserin along with lower toxicity.
Carotane sesquiterpenes from Ferula vesceritensis: in silico analysis as SARS-CoV-2 binding inhibitors
Sesquiterpenes, 8α-anisate-dauc-4-ene-3,9-dione (webiol anisate) (1) and 10α-acetoxy-6α-benzoate-jaeschkeanadiol (2) as well as several analogues (3–12) were root extracted from Ferula vesceritensis.
Quinazoline-Schiff base conjugates: in silico study and ADMET predictions as multi-target inhibitors of coronavirus (SARS-CoV-2) proteins
Design of 2-phenylquinazolin-4(3H)one-trihydroxyphenyl Schiff base conjugates as COVID-19 therapy.
Automated multiplex nucleic acid tests for rapid detection of SARS-CoV-2, influenza A and B infection with direct reverse-transcription quantitative PCR (dirRT-qPCR) assay in a centrifugal microfluidic platform
Thor: Ragnarok was so much funnier than you could ever expect it to be, and it's all thanks to the genius of Jeff Goldbloom combined with the genius of Taika Waititi—the latter of whom both directed the movie AND played a extremely earnest dude made out of rocks.
The price of U.S. benchmark West Texas Intermediate crude, which is traded on the New York Mercantile Exchange, has been kept lower by problems transporting the oil to markets. Those troubles have eased recently, but Sabine Schels, head of fundamental commodity research at Bank of America Merrill Lynch, doubts the problems will disappear.
A modular microarray imaging system for highly specific COVID-19 antibody testing
Development of a tablet PC-based portable device for colorimetric determination of assays including COVID-19 and other pathogenic microorganisms
Zhang Guoli to host 2014 Spring Festival Gala
German Three:Mercedes-Benz begins to sag as new lower-priced Benz’s inevitably erode its once invincible “the best or nothing” status. At BMW, imminent arrival of a new 7-series cements its status as the preferred brand of Scarsdale, Shaker Heights, and Santa Monica. A new A3, starting at $30, 795, should nicely lift Audi’s sales beyond 2014’s 15% climb, and a new Q7 SUV should nicely lift profits.
Inhibition of SARS-CoV-2 main protease by phenolic compounds from Manilkara hexandra (Roxb.) Dubard assisted by metabolite profiling and in silico virtual screening
警方在屋内查出一柄40口径的Smith & Wesson半自动手枪，目前正在进行弹道测试，检查器是否牵涉其他犯罪活动。
Rapid prediction of possible inhibitors for SARS-CoV-2 main protease using docking and FPL simulations
A combination of Autodock Vina and FPL calculations suggested that periandrin V, penimocycline, cis-p-Coumaroylcorosolic acid, glycyrrhizin, and uralsaponin B are able to bind well to SARS-CoV-2 Mpro.
Curcumin to inhibit binding of spike glycoprotein to ACE2 receptors: computational modelling, simulations, and ADMET studies to explore curcuminoids against novel SARS-CoV-2 targets
Amid rising pollution and a strengthening yuan, the capital city saw its tourist numbers drop to 4.20 million visits from January to November from 5.01 million visits in 2012, according to China Daily, citing a report from China Tourism Academy and Beijing Commission of Tourism Development. An earlier report based on a survey of domestic travel agents showed that visitors to the capital declined by roughly 50% in the first three-quarters of the year compared with a year earlier.
A density functional theory study on silver and bis-silver complexes with lighter tetrylene: are silver and bis-silver carbenes candidates for SARS-CoV-2 inhibition? Insight from molecular docking simulation
Directing for a Mini-Series or Movie: Susanne Bier, “The Night Manager”
An in silico perception for newly isolated flavonoids from peach fruit as privileged avenue for a countermeasure outbreak of COVID-19
3′-Hydroxy-4′-methoxy-chroman-7-O-β-D-glucopyranoside 4, together with three known compounds, ferulic acid heptyl ester 1, naringenin 2, and 4,2′,4′-trihydroxy-6′-methoxychalcone-4′-O-β-D-glucopyranoside 3, was isolated from peach fruits.
Understanding the role of galectin inhibitors as potential candidates for SARS-CoV-2 spike protein: in silico studies
Characterization of a commercially-available, low-pressure UV lamp as a disinfection system for decontamination of common nosocomial pathogens on N95 filtering facepiece respirator (FFR) material
Tracey and Viv Williams, a British couple, dressed as the green cartoon ogres from Shrek at their wedding held recently. Tracy, 33, made a lovely Princess Fion
A facile assay for rapid detection of COVID-19 antibodies
Potential role of medicinal plants and their constituents in the mitigation of SARS-CoV-2: identifying related therapeutic targets using network pharmacology and molecular docking analyses
IE商学院的在线MBA持续吸引着高素质的学员。其半数校友在入读时为高管级别，为所有上榜学院中比例最高的。该学院的在线MBA学员在毕业3年后的平均年薪最高，为17.9万美元，比薪资排第二位的（巴布森学院(Babson College)奥林商学院(Olin Business School)）高出约3万美元。
Gisele, 37, came in second place, having earned $17.5 million, marking the first year she has not headed up the line-up since 2002.
Remdesivir-bound and ligand-free simulations reveal the probable mechanism of inhibiting the RNA dependent RNA polymerase of severe acute respiratory syndrome coronavirus 2
Consensus virtual screening of dark chemical matter and food chemicals uncover potential inhibitors of SARS-CoV-2 main protease
Clinical decision support tool and rapid point-of-care platform for determining disease severity in patients with COVID-19
It is the continual shrinkage of components that have unleashed the explosion of computing power and enabled these gadgets to be accessible to people across the world.
Whole-genome sequence analysis and homology modelling of the main protease and non-structural protein 3 of SARS-CoV-2 reveal an aza-peptide and a lead inhibitor with possible antiviral properties
“We have not really assumed China will get better in the rest of the year,” said James Quincey, Coca-Cola’s chief operating officer. He said juice sales fell double digits in the second quarter in the country and Coca-Cola drinks dropped single digits.
Molecular docking reveals the potential of Salvadora persica flavonoids to inhibit COVID-19 virus main protease
Molecular docking reveals the potential of Salvadora persica flavonoids to inhibit COVID-19 virus main protease.
Smartphone-based multiplex 30-minute nucleic acid test of live virus from nasal swab extract
Anti-HIV drug repurposing against SARS-CoV-2
James Bond Themes 2. "GoldenEye" by Tina Turner
Length-scale dependence of protein hydration-shell density
'Chinese clients are not only buying in Asia but in New York and Geneva as well.'
“A hiring manager was reading the wrong person’s resume.”
High antiviral activity of mercaptoethane sulfonate functionalized Te/BSA nanostars against arterivirus and coronavirus
12. Zoho CRM
Similarly, Katy Perry was initially granted a visa to perform at the show in Shanghai but Chinese officials soon changed their mind. This, it has been claimed, is because the singer carried a Taiwanese flag and wore a dress covered in sunflowers during a 2015 concert in Taiwan.
A handheld continuous-flow real-time fluorescence qPCR system with a PVC microreactor
7. Viceroy's House
About this collection
Last year, the General Administration of Quality Supervision, Inspection and Quarantine conducted random quality inspections on 1,013 batches of such products, including consumer goods such as toys, paper diapers, clothing and kitchenware, with 415 found to be substandard, accounting for 40.9 percent of all sampled products, according to Han Yunping, spokesman for the administration.